I-Dipeptides

I-L-α-dipeptides (i-dipeptides) ayizange ifundwe cishe njengoba okuningi kunamaprotheni nama-amino acid.Ucwaningo oluyinhloko lwenziwe ku-L-aspartyl-L-phenylalanine methylester (aspartame) kanye ne-Ala-Gln (Lalanyl-L-glutamine) ngoba asetshenziswa emikhiqizweni yokuhweba edumile.Ngaphezu kwaleli qiniso, esinye isizathu esenza ukuthi ama-dipeptide amaningi angahlolisiswa kahle ukuthi ukukhiqizwa kwe-dipeptide akunazo izinqubo zokukhiqiza ezisebenzayo, nakuba kubikwe izindlela ezimbalwa zamakhemikhali nezekhemoenzymatic.

I-Carnosine - isibonelo se-dipeptide
Kuze kube muva nje, kuye kwasungulwa izindlela ezintsha zokwenziwa kwe-dipeptide lapho ama-dipeptides akhiqizwa khona ngezinqubo zokuvutshelwa.Ama-dipeptide athile anamandla ahlukile okuphila, awavumela ukuthi asheshise ukusetshenziswa kwe-dipeptide emikhakheni eyahlukene yocwaningo lwesayensi.I-L-α-dipeptides yakhiwe ibhondi ye-peptide engaxaki kakhulu yama-amino acid amabili, nokho awatholakali kalula ngokuyinhloko ngenxa yokungabizi kakhulu kwezinqubo zokukhiqiza.Kodwa-ke, ama-dipeptides anemisebenzi ethakazelisa kakhulu, futhi ulwazi lwesayensi oluwazungezile luyanda.Lokhu kushiya abacwaningi abaningi benecala lokuthuthukisa izinqubo ezisebenza kahle nezingabizi kakhulu zokukhiqizwa kwe-dipeptide.Uma lo mkhakha usucwaningwa ngokugcwele, kulindeleke ukuthi sifunde okwengeziwe mayelana nokuthi abaluleke kangakanani ama-peptide.

I-Dipeptides inemisebenzi emibili eyisisekelo, okuyi:
1. Okuphuma kuma-amino acid
2. I-dipeptide ngokwayo

Njengokususelwe kuma-amino acid, ama-dipeptides, kanye nama-amino acid awo aqukethe izici ezihlukahlukene ze-physiochemical, kodwa ngokuvamile abelana ngemiphumela efanayo yomzimba.Lokhu kungenxa yokuthi ama-dipeptide acekelwa phansi abe ama-amino acid ahlukene ezintweni eziphilayo, anezakhiwo ezihlukahlukene ze-physicochemical.Isibonelo, i-L-glutamine (Gln) i-heat-labile, kuyilapho i-Ala-Gin (L-alanyl-L-glutamine) ibekezelela ukushisa.

Ukuhlanganiswa kwamakhemikhali e-dipeptides kwenzeka kanje:
1. Wonke amaqembu e-dipeptide asebenzayo avikelekile (ngaphandle kwalawo abambe iqhaza ekwakheni isibopho se-peptide yama-amino acid).
2. I-amino acid evikelwe yeqembu le-carboxyl yamahhala iyasebenza.
3. I-amino acid ecushiwe ihlangana nenye i-amino acid evikelwe.
4. Amaqembu avikelayo aqukethwe ngaphakathi kwe-dipeptide ayasuswa.