Sisebenzisa amakhukhi ukuthuthukisa ulwazi lwakho.Ngokuqhubeka nokuphequlula le webhusayithi, uyavumelana nokusebenzisa kwethu amakhukhi.Ulwazi olwengeziwe.
Kunesidingo esiphuthumayo sokuthi imibiko yocwaningo lwe-biomedical yamangqamuzana ezilwane ezincelisayo ifaneke kakhudlwana futhi inemininingwane eminingi, futhi ilawule kangcono futhi ilinganise izimo zemvelo zesiko lamaseli.Lokhu kuzokwenza ukumodela kwe-physiology yomuntu kunembe kakhudlwana futhi kube nomthelela ekwenziweni kabusha kocwaningo.
Ithimba lososayensi be-KAUST nozakwabo e-Saudi Arabia nase-United States bahlaziye amaphepha angama-810 akhethwe ngokungahleliwe emigqeni yeseli yezilwane ezincelisayo.Ezingaphansi kuka-700 zazo ezihilela izivivinyo ze-cell culture ngayinye eziyi-1,749, okuhlanganisa nedatha efanele ngezimo zemvelo zomkhakha wosikompilo lwamaseli.Ukuhlaziya kwethimba kukhombisa ukuthi mkhulu umsebenzi okufanele wenziwe ukuze kuthuthukiswe ukuhlobana nokukhiqizwa kabusha kwezifundo ezinjalo.
Hlakulela amaseli ku-incubator elawulwayo ngokuya ngamaphrothokholi ajwayelekile.Kodwa amangqamuzana azokhula futhi “aphefumule” ngokuhamba kwesikhathi, eshintshanisa igesi nendawo ezungezile.Lokhu kuzothinta indawo ezungezile ezikhula kuyo, futhi kungase kuguqule i-asidi yesiko, umoya-mpilo oncibilikisiwe, namapharamitha e-carbon dioxide.Lezi zinguquko zithinta ukusebenza kwamangqamuzana futhi zingenza isimo somzimba sihluke esimweni esisemzimbeni womuntu ophilayo.
"Ucwaningo lwethu lugcizelela izinga ososayensi abangakunaki ngalo ukuqapha nokulawula indawo yamaselula, futhi ngezinga imibiko eyenza bakwazi ukufinyelela iziphetho zesayensi ngezindlela ezithile," kusho uKlein.
Isibonelo, abacwaningi bathola ukuthi cishe isigamu samaphepha okuhlaziya ahlulekile ukubika izinga lokushisa kanye nezilungiselelo ze-carbon dioxide zamasiko amaseli abo.Ngaphansi kwe-10% ibike okuqukethwe kwe-oksijini emkhathini ku-incubator, futhi ngaphansi kuka-0.01% babike i-acidity yendawo.Awekho amaphepha abikiwe nge-oxygen encibilikile noma i-carbon dioxide kwabezindaba.
Simangele kakhulu ukuthi abacwaningi baye bangazinaki kakhulu izici zemvelo ezigcina amazinga afanele ngokomzimba phakathi nayo yonke inqubo yesiko lamaseli, njenge-acidity yesiko, nakuba kwaziwa kahle ukuthi lokhu kubalulekile ekusebenzeni kweseli.”
Ithimba liholwa uCarlos Duarte, isazi sezinto eziphilayo zasolwandle e-KAUST, kanye no-Mo Li, isazi sebhayoloji ye-stem cell, ngokubambisana no-Juan Carlos Izpisua Belmonte, isazi sezinto eziphilayo esithuthukayo e-Salk Institute.Njengamanje unguprofesa ovakashele e-KAUST futhi uncoma ukuthi ososayensi be-biomedical bathuthukise imibiko ejwayelekile kanye nezinqubo zokulawula nokulinganisa, ngaphezu kokusebenzisa izinsimbi ezikhethekile zokulawula imvelo yesiko lezinhlobo ezahlukene zamaseli.Amajenali esayensi kufanele asungule izindinganiso zokubika futhi adinga ukuqapha nokulawulwa okwanele kwe-acidity yemidiya, umoya-mpilo oncibilikisiwe kanye nesikhutha.
"Ukubika okungcono, ukulinganisa, nokulawula izimo zemvelo zesiko lamaseli kufanele kuthuthukise ikhono lososayensi lokuphinda futhi bakhiqize imiphumela yokuhlola," kusho u-Alsollami."Ukubhekisisa kungadala izinto ezintsha ezitholakele futhi kwandise ukubaluleka kocwaningo lwangaphambi komtholampilo emzimbeni womuntu."
“Usikompilo lwamangqamuzana ezilwane ezincelisayo luyisisekelo sokwenziwa kwemithi yokugomela amagciwane nezinye izindlela zobuchwepheshe bezinto eziphilayo,” kuchaza usosayensi wasolwandle uShannon Klein."Ngaphambi kokuhlolwa ezilwaneni nakubantu, asetshenziselwa ukutadisha i-basic cell biology, ukuphindaphinda izindlela zezifo, nokutadisha ubuthi benhlanganisela yezidakamizwa emisha."
Klein, SG, njll. (2021) Ukunganakwa okuvamile kokulawulwa kwemvelo kusiko lamaseli ezincelisayo kudinga izinqubo ezihamba phambili.Ubunjiniyela Bezemvelo Bezokwelashwa.doi.org/10.1038/s41551-021-00775-0.
Tags: B cell, cell, cell culture, incubator, mammalian cell, ukukhiqiza, umoya-mpilo, i-pH, i-physiology, preclinical, ucwaningo, T cell
Kule ngxoxo, uSolwazi John Rossen ukhulume ngokulandelana kwesizukulwane esilandelayo kanye nomthelela wako ekuxilongweni kwezifo.
Kule ngxoxo, i-News-Medical ikhulume noSolwazi Dana Crawford ngomsebenzi wakhe wocwaningo ngesikhathi sodlame lwe-COVID-19.
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Isikhathi sokuthumela: Sep-07-2021
